Endocrine Abstracts

Many causes of levothyroxine malabsorption have been described in the literature such as celiac disease, giardiasis, severe liver cirrhosis and drug interactions. A 27-year-old woman admitted to our institution with overt hypothyroidism symptoms. She had total thyroidectomy for thyroid papiller carcinoma and was using 400 μg/day levothyroxine (LT4). Her serum free thyroxine (fT4), free triiodothyronine (fT3) and thyrotropin stimulating hor...

Aims: Glomerular and tubulointerstitial damage plays a role in renal function failure in diabetic patients. While both serum and urine levels of neutrophil gelatinase-associated lipocalin (NGAL) show significantly increased levels in acute renal pathologies, the NGAL increase in active phase indicates a reversible condition in chronic cases. In this study, we determined if urinary excretion of NGAL can be used as an early indicator of diabetic nephropathy, which causes chronic...

Weight gain and obesity are frequent problems after kidney transplantation. Potential causes of weight gain are use of immunosuppressive drugs and changes in life style such as dietary intake and insufficient physical activity. This study aimed to evaluate the different general and abdominal obesity criterias and post-transplant weight changes in kidney transplant recipients.Methods: This prospective study included consecutive 112 (62 females, 50 males) ...

Background: Isotretinoin has been used for many years to treat moderate or severe nodulocystic acne, disorders of sebaceous gland and keratinization and in the prevention of skin cancer. Certain types of retinoids may cause abnormalities in serum thyroid function tests by suppressing thyroid stimulating hormone (TSH). However, it is uncertain whether systemic isotretinoin has any effect on thyroid functions.Case: 18 years old woman has admitted to our ho...

Introduction: The most frequently secreted hormone in pituitary adenomas is prolactin, but prolactin and growth hormone co-secretion are also seen at not an uncommon frequency. Co-secretion of growth hormone has also been reported after long-term follow up in the prolactinoma patients which well controlled with cabergoline therapy. In this case report, we aimed to discuss the results of cabergoline therapy in a case of co-secreting GH and prolactine with a normal IGF1 level an...

Tuberculosis (TB) infection incidence is still high among solid organ transplant recipients. TB in recipients can manifest several years after transplantation, especially in developing countries. Atypical clinical presentations and extrapulmonary involvement are not uncommon in recipients. Herein, we reported a kidney transplant recipient with TB abscess who admitted with fever and swelling on thyroid gland region.Case: A 57-year old female recipient und...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma and is derived from thyroid follicular cells which originate from the endodermal origin. In contrast, medullary thyroid carcinoma (MTC) is rare and originates from the parafollicular C-cells, which are commonly thought to be derived from the ectodermal neural crest. Co-incidence of the two condition on the same patient is so rare. We describe a case of concurrent MTC and PTC occurring in the s...

Introduction: Pheochromocytomas are rare catecolamin-secreting neoplasms. The classic triad of symptoms in patients with a pheochromocytoma consists of episodic headache, sweating and tachycardia. Gastrointestinal spectrums have been reported such as chronic constipation, intestinal pseudo-obstruction or even intestinal perforation. We describe patient who presented with non-mechanical bowel obstruction and interestingly hydronephrosis and acute kidney injury as a consequence ...

Vitamin B12 or cobalamin is mainly found in animal origin food products. The frequency of vitamin B12 deficiency varies between 3 and 40% in different populations. Metformin is the first-choice therapy for type 2 diabetics having some side effects, one of them being vitamin B12 malabsorption. The study aimed to evaluate serum levels of vitamin B12 in diabetic and non-diabetic patients with cobalamin deficiency.Methods: Medical records of subjects having ...

Introduction: High thyroid hormone levels with unsupressed TSH (atypical hyperthyroxinemia) is one of the difficult endocrinologic conditions. When the conditions leading to euthyroid hyperthyoxinism are excluded, TSH secreting pituitary adenomas (TSHoma) and thyroid hormone resistance beta syndrome (THRB) lead to this picture as rare diseases. This report aims to evaluate the diagnostic and therapeutic stages in the case of TSH-secreting pituitary microadenoma which response ...